Renal potassium channels: An overview
نویسندگان
چکیده
منابع مشابه
Potassium Channels and Human Epileptic Phenotypes: An Updated Overview
Potassium (K(+)) channels are expressed in almost every cells and are ubiquitous in neuronal and glial cell membranes. These channels have been implicated in different disorders, in particular in epilepsy. K(+) channel diversity depends on the presence in the human genome of a large number of genes either encoding pore-forming or accessory subunits. More than 80 genes encoding the K(+) channels...
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Progressive renal fibrosis is a common outcome of almost all forms of renal damage, including diabetic nephropathy. Fibrosis leads to chronic kidney failure and, eventually, dialysis or transplantation (1–3). Although much is known about the molecular background and mediators that prompt fibroblasts or transdifferentiated kidney cells to release collagen and matrix (4–6), the search for a uniqu...
متن کاملMolecular diversity and regulation of renal potassium channels.
K(+) channels are widely distributed in both plant and animal cells where they serve many distinct functions. K(+) channels set the membrane potential, generate electrical signals in excitable cells, and regulate cell volume and cell movement. In renal tubule epithelial cells, K(+) channels are not only involved in basic functions such as the generation of the cell-negative potential and the co...
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Ion channels are well-known functional proteins, and their activity can be directly estimated by monitoring ion currents through channel proteins using the patch-clamp technique (Hamill et al., 1981), which is a fine tool for the investigation of not only ion channels, but also the membrane current and membrane potential of the whole cell. Many investigators have applied the patch-clamp techniq...
متن کاملMolecular identity and regulation of renal potassium channels.
K channels are ubiquitous in animal cells, where they are involved in a variety of physiological functions. In epithelial cells of the kidney, K channels are primarily involved in maintaining membrane potential, recycling and secreting K and regulating cell volume. As many renal K channels have now been studied or identified at the molecular level by means of a variety of approaches, including ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1995
ISSN: 0085-2538
DOI: 10.1038/ki.1995.382